Agent nonsedating antihistamine Live two way chat

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Several of the older drugs, called first-generation antihistamines, bind non-selectively to H receptors in the central nervous system as well as to peripheral receptors, and can produce sedation, inhibition of nausea and vomiting, and reduction of motion sickness.

Additional effects vary with the individual drug used.

This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.

Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.

Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.

In 2014 antihistamines such as desloratadine were found to be effective as adjuvants to standardized treatment of acne due to their anti-inflammatory properties and their ability to suppress sebum production.

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