She stated that among the older ones (tricyclics), Imipramine, was the best for sedation. However, neither medication has been clearly shown to be effective in treating panic disorder, although there are a few reports supporting this.
I don't want to increase my heart rate and am looking for one of the newer ones. There are more consistent studies supporting treatment of panic disorder with the SSRIs (Paxil, Zoloft, Celexa, Prozac), Effexor, or benzodiazepines (Xanax, Klonopin, Ativan).
Antidepressants are prescribed most often for clinical depression and severe cases of depression.
Jones, Shinar, and Walsh (2003) provide a breakdown of the subclasses of antidepressants with examples.
This lead to a trend of many companies developing tricyclic antidepressants with different three ring structures from Imipramine.
Tricyclic antidepressants became commonly prescribed for the treatment of major depression and were considered very effective at managing symptoms.
These drugs are known for their specific chemical structure consisting of three rings of atoms, hence being referred to as “tri”-cyclic.Analytical epidemiological studies, using predominantly older drivers, have documented increased crash risks, with a relative risk of 2.3 Leveille, Buchner, Koepsell, Mc Closkey, Wolf, and Gagner (1994).Ramaekers (2003) summarized the major results of all studies published from 1983 to 2000 that investigated the effect of antidepressants on driving performance.Mirtazapine is a newer antidepressant that exhibits both noradrenergic and serotonergic activity.It is at least as effective as the older antidepressants for treating mild to severe depression. Although agranulocytosis is the most serious side effect, it is rare (approximately one in 1,000) and usually reversible when the medication is stopped. Many clinicians consider mirtazapine a second-line or even third-line antidepressant, to be used when older antidepressants are not tolerated or are ineffective.